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(6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sulfate

Cefoselis sulfate

CAS: 122841-12-7

Molecular Formula: C19H24N8O10S3

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  5. (6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sulfate

(6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sulfate - Names and Identifiers

Name Cefoselis sulfate
Synonyms Winsef
FK 037
sulfuric acid
FK 037 Sulfate
CEFOSELIS SULFATE
Cefoselis sulfate
7-[[2-(2-amino-4-thiazolyl)-2-methoxyimino-1-oxoethyl]amino]-3-[[2-(2-hydroxyethyl)-3-imino-1-pyrazolyl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-7-[[(2E)-2-(2-aminothiazol-4-yl)-2-methoxyimino-acetyl]amino]-3-[[2-(2-hydroxyethyl)-3-imino-pyrazol-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R,E)-7-(2-(2-aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-((2-(2-hydroxyethyl)-3-imino-2,3-dihydropyrazol-1-yl)methyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid, sulfate
(6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sulfate
CAS 122841-12-7
EINECS 1533716-785-6
InChI InChI=1/C19H22N8O6S2.H2O4S/c1-33-24-12(10-8-35-19(21)22-10)15(29)23-13-16(30)27-14(18(31)32)9(7-34-17(13)27)6-25-3-2-11(20)26(25)4-5-28;1-5(2,3)4/h2-3,8,13,17,20,28H,4-7H2,1H3,(H4,21,22,23,29,31,32);(H2,1,2,3,4)/b24-12+;/t13-,17-;/m1./s1

(6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sulfate - Physico-chemical Properties

Molecular FormulaC19H24N8O10S3
Molar Mass620.64
Storage Condition2-8℃
In vitro studyCefoselis concentration-dependently inhibited GABA-induced currents with an IC50 of 185 mM. Cefoselis had good anti-staphylococcal activity against strains of MSSA and was as active against multidrug-resistant enterobacteria as the other two compounds, Cefepime and Cefpirome. Cefoselis appeared dose-dependently in the extracellular fluid of the brain in proportion to its blood levels. Cefoselis, a novel parenteral cephalosporin active against Gram-positive and Gram-negative aerobic clinical strains.
In vivo studyIn normal rats, Cefoselis caused a large increase in extracellular glutamate concentration. Convulsions induced by Cefoselis (50 mg/animal) were modified by 5-methyl -10, 11-dihydro-5h-dibenzo [a,d] cycloheptene-5, 10-imine (MK-801), pretreatment with diazepam and phenobarbital prevented,(ED(50) values (mg/kg) of 0.78,1.59 and 33.0, respectively), but was not affected by carbamazepine or phenytoin.

(6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sulfate - Reference

Reference
Show more
1. [IF=3.681] Dong Wei-chong et al."A Direct Injection Technique to Improve Biosafety to Analyze Levetiracetam Concentrations in Human Serum and Its Application in Therapeutic Drug Monitoring."Ther Drug Monit. 2021 Apr;43(2):292-297

(6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sulfate - Preparation solution concentration reference

 1mg5mg10mg
1 mM1.611 ml8.056 ml16.113 ml
5 mM0.322 ml1.611 ml3.223 ml
10 mM0.161 ml0.806 ml1.611 ml
5 mM0.032 ml0.161 ml0.322 ml
Last Update：2024-01-02 23:10:35
(6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sulfate
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CAS: 122841-12-7
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Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Cefoselis sulfate Visit Supplier Webpage Request for quotation
CAS: 122841-12-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
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(6R-(6alpha,7beta(Z)))-7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid sulfate
D-serine-obzl HCL
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